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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPM1
All Species:
22.12
Human Site:
S222
Identified Species:
60.83
UniProt:
P06748
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06748
NP_002511.1
294
32575
S222
K
P
S
S
T
P
R
S
K
G
Q
E
S
F
K
Chimpanzee
Pan troglodytes
XP_001151859
290
32094
S218
K
P
S
S
T
P
R
S
K
G
Q
E
S
F
K
Rhesus Macaque
Macaca mulatta
XP_001092017
289
31951
S217
K
P
S
S
T
P
R
S
K
G
Q
E
S
F
K
Dog
Lupus familis
XP_536432
294
32601
T222
S
K
P
S
T
P
R
T
K
G
Q
E
S
F
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61937
292
32542
S220
L
K
P
S
T
P
R
S
K
G
Q
E
S
F
K
Rat
Rattus norvegicus
P13084
292
32542
S220
L
K
P
S
T
P
R
S
K
G
Q
E
S
F
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508370
280
30882
K208
K
P
S
T
P
K
S
K
G
S
E
S
F
K
K
Chicken
Gallus gallus
P16039
294
32614
T222
P
S
T
P
A
S
K
T
K
T
P
D
S
K
K
Frog
Xenopus laevis
P07222
299
33514
P223
T
Q
K
T
P
K
T
P
E
Q
K
G
K
Q
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
97.2
98.3
N.A.
93.5
93.5
N.A.
76.8
69.7
65.5
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.6
98.3
99.3
N.A.
97.6
97.6
N.A.
87.4
84
79.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
73.3
N.A.
80
80
N.A.
26.6
20
0
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
80
80
N.A.
40
46.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
12
% D
% Glu:
0
0
0
0
0
0
0
0
12
0
12
67
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
12
67
0
% F
% Gly:
0
0
0
0
0
0
0
0
12
67
0
12
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
45
34
12
0
0
23
12
12
78
0
12
0
12
23
89
% K
% Leu:
23
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
12
45
34
12
23
67
0
12
0
0
12
0
0
0
0
% P
% Gln:
0
12
0
0
0
0
0
0
0
12
67
0
0
12
0
% Q
% Arg:
0
0
0
0
0
0
67
0
0
0
0
0
0
0
0
% R
% Ser:
12
12
45
67
0
12
12
56
0
12
0
12
78
0
0
% S
% Thr:
12
0
12
23
67
0
12
23
0
12
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _